About Insomnia

Understanding Insomnia
Understanding Insomnia
Insomnia Definition

American Psychiatric Association DSM 5 criteria defines Insomnia as a condition in which people have the following *:

Insomnia is not solely defined by the amount of sleep, but by quality and type as well.

*American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Association; 2013
Insomnia Epidemiology

Symptoms occur in 33 to 50% of the adult population *,†

* Dopp JM, Phillips BG. Sleep–Wake Disorders. In: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey L. eds. Pharmacotherapy: A Pathophysiologic Approach, 10e New York, NY: McGraw-Hill
† Roth T. Insomnia: definition, prevalence, etiology, and consequences. J Clin Sleep Med. 2007;3(5 Suppl):S7-10.
America Insomnia Survey

* Walsh JK, Coulouvrat C, Hajak G, et al. Nighttime insomnia symptoms and perceived health in the America Insomnia Survey (AIS). Sleep. 2011;34(8):997- 1011.

The American Insomnia survey found more respondents complaining about difficulty staying asleep (61%) and early morning awakening (52%) than difficulty falling asleep (38%)

The American Insomnia survey statistics


Insomnia & Comorbidities
Insomnia & Depression*

Approximately 40% of adults with insomnia also have a coexisting psychiatric disorder, the most common being depression. Certain psychiatric conditions may be linked to Insomnia and can even be considered a diagnostic criteria. Psychological issues can lead to difficulty falling asleep, insomnia can lead to mood swings and shift in hormones. Studies suggest insomnia can trigger or worsen depression. The good news is that both conditions are treatable.

Insomnia & Anxiety*

Trouble falling asleep can cause someone to worry or be nervous. Certain anxiety symptoms that may lead to Insomnia include:

Anxiety may lead to problems with trouble falling asleep or maintenance of sleep throughout night. Once it starts happening on few occasions you may start feeling anxious and it triggers difficulty falling asleep. In patients comorbid with both, anxiety showed before insomnia in most instances. Various cognitive and mind-body techniques maybe helpful to people to facilitate falling asleep and relive anxiety.

Insomnia & Lifestyle

Unhealthy lifestyle and irregular sleeping habits can create or initiate causes that may lead to insomnia. Some specific lifestyle factors may include:

* Roth T. Insomnia: definition, prevalence, etiology, and consequences. J Clin Sleep Med. 2007;3(5 Suppl):S7-10.
† Lopes CS, Robaina JR, Rotenberg L. Epidemiology of insomnia: prevalence and risk factors In: Sahoo S, editor. Can’t sleep? Issues of being an insomniac. Rijeka: InTech; 2012. p. 3-22.


Indication

DORAL (Quazepam) is indicated for the treatment of insomnia characterized by difficulty falling asleep, frequent nocturnal awakenings, and/or early morning awakenings.

Important Safety Information ▲ expand

WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS
Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death [see Warnings and Precautions (5.1), Drug Interactions (7)]. Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation.

Doral can produce daytime impairment, and this risk increases with dose and concomitant use of other CNS depressants. If insomnia worsens or fails to remit after 7 to 10 days of treatment, this might be indication of an underlying illness. Doral is contraindicated in patients with a known hypersensitivity to quazepam or other benzodiazepines, established or suspected sleep apnea, or chronic pulmonary insufficiency. Rare cases of severe anaphylactic reactions including angioedema and dyspnea have been reported. Complex behaviors, such as sleep driving or sleep eating, have been reported with the use of sedative-hypnotics. Immediately evaluate the onset of any new behavioral changes. Benzodiazepines may worsen depression, and appropriate precautions should be considered in at risk patients. For a full list of warnings and precautions, please refer to the full prescribing information.